Findings that are more than the sum of their parts.
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Basically, Science

The research newsletter from ISTA


🔗 Issue #4 — Emergence

Editor Profile Will Campbell
Editor

What happens when results reveal more than we anticipated?


The natural world doesn’t operate in isolation. Interactions, collaborations, and complex systems constantly produce outcomes greater than the sum of their parts.

Scientists often seek to understand these emergent effects—patterns and behaviors that arise through many elements working together. Sometimes, the results go beyond initial expectations, opening up new questions and directions. 


In this edition we look at how an ant colony works together to defend against disease, how an ancient plant type uses an unexpected microbe in reproduction, and how our brain stabilizes movement in real time.

 

Ants cleaning each other

© Sina Metzler & Roland Ferrigato

‌Ants Work Together to Fight Disease

Researchers at ISTA and Comenius University Bratislava have shown how ants decide when to groom their nest mates to reduce the spread of infection. What appears to be instinctive cooperation instead reveals a self-organising system, where group-level immunity emerges from individual decisions.

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Reflections of co-first authors Tomas Vega-Zuniga and Olga Symonova

‌The Brain's Steady-Cam System Uncovered

Our eyes and heads move constantly, but the world stays steady. Neuroscientists at ISTA have found that a small region of the brain helps correct for motion blur in real time. What we see is not a raw feed, but a refined image emerging from many inputs working together.

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Microscopic view of an embryo developing

© Fabrèges & Corominas Murtra et al./Science

‌An Embryonic Journey from Chaos to Structure

An international team of researchers, including ISTA's Edouard Hannezo, has mapped how mammalian embryos develop from disordered clusters of cells into structured organisms. Despite the apparent randomness in individual cell movements and divisions, the embryos consistently form robust structures.

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Hidden in the damp corners of forest floors, the liverwort Marchantia polymorpha quietly unfurls its leaves. Within its cells lies a molecular relic from another world—one that began, not in plants, but in bacteria.


Xiaoqi Feng's research group at ISTA have uncovered a DNA marker once thought to belong only to microbes. In bacteria, it’s part of the immune system. In Marchantia, it now shapes the way sperm cells form and move, making it essential for the plant’s ability to reproduce.

 

‌"This might be one of nature’s ad-hoc events that boosted evolution." — Xiaoqi Feng

 

Somehow, across evolutionary time, a fragment of bacterial code has become part of this plant’s 'sex life', repurposed to power something as fundamental as reproduction. And that raises an even larger question. If Marchantia has made such use of this foreign tool, might other species have done the same? The search is now on to find out whether this marker appears elsewhere in the tree of life.
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‌Editor's picks

Sculpture of a brain in the snow

© Maria Cristina Travaglio

‌Sleep Keeps Memories Fresh

‌Neuroscientists provide new insight into why sleep is so important for learning and memory. By reorganizing neural activity, the brain strengthens memories of learned tasks. This process illustrates how complex memory consolidation emerges from the coordinated activity of neurons during sleep.

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Artists impression of a molecule with building blocks

‌New Blacksmith Technique Used to Form Molecular Bonds

With an innovative technique, the Pallacci Group at ISTA has used swimming bacteria to build tiny, spinning structures from scratch. Dropping microscopic particles into a bath of E. coli, similar to how a blacksmith quenches hot metal in water, the particles take shape, guided by the bacteria’s own motion.

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In Profile

‌How can Dead Matter be Brought to Life?


Research group leader Anđela Šarić is determined to find out and shares her approach to understanding life.


Living organisms are incredibly complex. They can reproduce, move, learn, adapt, and evolve—abilities that clearly set them apart from non-living things. But interestingly, both living and non-living matter are made from the same basic ingredients. For instance, carbon atoms that build pencils are no different from those that build living organisms. So, where do the special properties of life come from?


We believe the key lies in how the building blocks of matter are organized, how they interact, and—most importantly—how they use and disperse energy across different scales.


Even though the molecules in living systems follow the same physical laws as those in non-living matter, their collective behavior creates new, complex functions. This is called emergence—when the whole is more than just the sum of its parts.

Andela Saric on the ISTA campus

Anđela Šarić 

When these systems also consume energy, they move out of equilibrium, which is essential for life. For example, protein molecules can use energy to assemble into filaments that help cells divide and organisms grow. On the other hand, when energy use stops, harmful structures like protein aggregates can form, which are linked to diseases such as Alzheimer’s.

Understanding how molecules can come together to form complex, evolving systems is a fascinating challenge. It opens the door to discovering new physical principles and building life-like or bio-inspired systems from the ground up.

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ISTA Campus

From Top Left Clockwise: ISTA Professors Zoltan Haiman, Johann Danzl, Tamás Hausl, Peter Jonas

‌Four ERC Grants: 10 Million Euro for ISTA

ISTA receives over 10 million euro by the European Research Council (ERC). Four research projects—in astrophysics, neuroscience, brain imaging, and mathematics—were awarded around 2.5 million euro each in the form of a competitive ERC Advanced Grant.

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